Human monocyte activation induced by an anti-CD14 monoclonal antibody
Identifieur interne : 001519 ( Main/Exploration ); précédent : 001518; suivant : 001520Human monocyte activation induced by an anti-CD14 monoclonal antibody
Auteurs : C. Schütt [Allemagne] ; B. Ringel [Allemagne] ; M. Nausch [Allemagne] ; V. Bažil [Tchécoslovaquie] ; V. Ho Ejší [Tchécoslovaquie] ; P. Neels [Allemagne] ; H. Walzel [Allemagne] ; L. Jonas [Allemagne] ; E. Siegl [Allemagne] ; H. Friemel [Allemagne] ; A. Plantikow [Allemagne]Source :
- Immunology Letters [ 0165-2478 ] ; 1988.
English descriptors
- Teeft :
- Allergie immunol, Cell line, Cell surface, Chemiluminescence, Chemiluminescence assay, Electron microscopy, Human monocytes, Immunol, Leucocyte typing, Mabs, Medical immunology, Monocyte, Monocyte activation, Monocyte surface, Mononuclear cells, Mouse igg2a, Opsonized, Opsonized zymosan, Oxford university press, Oxidative, Oxidative burst, Similar effect, Soluble form, Supernatant, White cell differentiation antigens, Zymosan.
Abstract
Abstract: An anti-CD14 mAb RoMo-1 rapidly induces in human monocytes a transient oxidative burst activity as detected by chemiluminescence assay. Pretreatment of these cells with the mAb markedly suppresses the monocyte chemiluminescence response to opsonized zymosan. In addition, the antibody induces a significant increase of IL-1 production and secretion by mononuclear cells, comparable to a similar effect of rIFN-γ or LPS. Electron microscopy demonstrates internalization of the CD14 molecules after interaction with the mAb in a characteristic receptor-like manner.
Url:
DOI: 10.1016/0165-2478(88)90162-9
Affiliations:
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Le document en format XML
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Siegl</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Immunology, Wilhelm Pieck University, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Friemel, H" sort="Friemel, H" uniqKey="Friemel H" first="H." last="Friemel">H. Friemel</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Immunology, Wilhelm Pieck University, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Plantikow, A" sort="Plantikow, A" uniqKey="Plantikow A" first="A." last="Plantikow">A. Plantikow</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Immunology, Wilhelm Pieck University, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunology Letters</title><title level="j" type="abbrev">IMLET</title><idno type="ISSN">0165-2478</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="321">321</biblScope><biblScope unit="page" to="327">327</biblScope></imprint><idno type="ISSN">0165-2478</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-2478</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allergie immunol</term><term>Cell line</term><term>Cell surface</term><term>Chemiluminescence</term><term>Chemiluminescence assay</term><term>Electron microscopy</term><term>Human monocytes</term><term>Immunol</term><term>Leucocyte typing</term><term>Mabs</term><term>Medical immunology</term><term>Monocyte</term><term>Monocyte activation</term><term>Monocyte surface</term><term>Mononuclear cells</term><term>Mouse igg2a</term><term>Opsonized</term><term>Opsonized zymosan</term><term>Oxford university press</term><term>Oxidative</term><term>Oxidative burst</term><term>Similar effect</term><term>Soluble form</term><term>Supernatant</term><term>White cell differentiation antigens</term><term>Zymosan</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: An anti-CD14 mAb RoMo-1 rapidly induces in human monocytes a transient oxidative burst activity as detected by chemiluminescence assay. Pretreatment of these cells with the mAb markedly suppresses the monocyte chemiluminescence response to opsonized zymosan. In addition, the antibody induces a significant increase of IL-1 production and secretion by mononuclear cells, comparable to a similar effect of rIFN-γ or LPS. Electron microscopy demonstrates internalization of the CD14 molecules after interaction with the mAb in a characteristic receptor-like manner.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Tchécoslovaquie</li></country><region><li>Bohême centrale</li></region><settlement><li>Prague</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Schutt, C" sort="Schutt, C" uniqKey="Schutt C" first="C." last="Schütt">C. Schütt</name></noRegion><name sortKey="Friemel, H" sort="Friemel, H" uniqKey="Friemel H" first="H." last="Friemel">H. Friemel</name><name sortKey="Jonas, L" sort="Jonas, L" uniqKey="Jonas L" first="L." last="Jonas">L. Jonas</name><name sortKey="Nausch, M" sort="Nausch, M" uniqKey="Nausch M" first="M." last="Nausch">M. Nausch</name><name sortKey="Neels, P" sort="Neels, P" uniqKey="Neels P" first="P." last="Neels">P. Neels</name><name sortKey="Plantikow, A" sort="Plantikow, A" uniqKey="Plantikow A" first="A." last="Plantikow">A. Plantikow</name><name sortKey="Ringel, B" sort="Ringel, B" uniqKey="Ringel B" first="B." last="Ringel">B. Ringel</name><name sortKey="Siegl, E" sort="Siegl, E" uniqKey="Siegl E" first="E." last="Siegl">E. Siegl</name><name sortKey="Walzel, H" sort="Walzel, H" uniqKey="Walzel H" first="H." last="Walzel">H. Walzel</name></country><country name="Tchécoslovaquie"><region name="Bohême centrale"><name sortKey="Bazil, V" sort="Bazil, V" uniqKey="Bazil V" first="V." last="Bažil">V. Bažil</name></region><name sortKey="Ho Ejsi, V" sort="Ho Ejsi, V" uniqKey="Ho Ejsi V" first="V." last="Ho Ejší">V. 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